STRINGSTRING
glnG glnG glnL glnL rpoN rpoN dusB dusB ntrY ntrY glnK glnK pnp pnp cysG cysG mutM mutM ACS39283.1 ACS39283.1 ACS38189.1 ACS38189.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glnGTwo-component sigma-54 specific nitrogen transcriptional regulator, Fis subfamily; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (490 aa)    
Predicted Functional Partners:
glnL
Two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL; Function of strongly homologous gene; enzyme.
 0.997
rpoN
Sigma N (sigma 54) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.879
dusB
tRNA-dihydrouridine synthase B; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family.
 
  
 0.811
ntrY
Nitrogen regulatory signal transduction histidine kinase NtrY; Function of strongly homologous gene; enzyme.
 
 0.793
glnK
Nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family.
   
 
 0.714
pnp
Polynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
      
 0.671
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
   
  
 0.670
mutM
Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
      
 0.662
ACS39283.1
Two-component system, chemotaxis family, sensor kinase CheA; Function of strongly homologous gene; enzyme.
  
 
 0.661
ACS38189.1
Transporter protein; Function of strongly homologous gene; transporter.
      
 0.606
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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