node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS41377.1 | apt | MexAM1_META1p3666 | MexAM1_META1p0425 | Putative Glutamine amidotransferase-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.940 |
ACS41377.1 | gmk | MexAM1_META1p3666 | MexAM1_META1p1978 | Putative Glutamine amidotransferase-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | 0.921 |
ACS41377.1 | guaA | MexAM1_META1p3666 | MexAM1_META1p3135 | Putative Glutamine amidotransferase-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.916 |
ACS41377.1 | guaB | MexAM1_META1p3666 | MexAM1_META1p3145 | Putative Glutamine amidotransferase-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.989 |
ACS41377.1 | hpt | MexAM1_META1p3666 | MexAM1_META1p3063 | Putative Glutamine amidotransferase-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Hypoxanthine phosphoribosyl transferase; Function of strongly homologous gene; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.925 |
ACS41377.1 | purA | MexAM1_META1p3666 | MexAM1_META1p0776 | Putative Glutamine amidotransferase-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.509 |
apt | ACS41377.1 | MexAM1_META1p0425 | MexAM1_META1p3666 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative Glutamine amidotransferase-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.940 |
apt | gmk | MexAM1_META1p0425 | MexAM1_META1p1978 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | 0.980 |
apt | guaA | MexAM1_META1p0425 | MexAM1_META1p3135 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.991 |
apt | guaB | MexAM1_META1p0425 | MexAM1_META1p3145 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.609 |
apt | guaD | MexAM1_META1p0425 | MexAM1_META1p1653 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. | 0.918 |
apt | hpt | MexAM1_META1p0425 | MexAM1_META1p3063 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyl transferase; Function of strongly homologous gene; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.936 |
apt | purA | MexAM1_META1p0425 | MexAM1_META1p0776 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.612 |
apt | purH | MexAM1_META1p0425 | MexAM1_META1p2535 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Bifunctional: IMP cyclohydrolase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.967 |
apt | xapA | MexAM1_META1p0425 | MexAM1_META1p3170 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthosine phosphorylase (purine nucleoside phosphorylase); The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.940 |
gmk | ACS41377.1 | MexAM1_META1p1978 | MexAM1_META1p3666 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Putative Glutamine amidotransferase-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.921 |
gmk | apt | MexAM1_META1p1978 | MexAM1_META1p0425 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.980 |
gmk | guaA | MexAM1_META1p1978 | MexAM1_META1p3135 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.968 |
gmk | guaB | MexAM1_META1p1978 | MexAM1_META1p3145 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.589 |
gmk | hpt | MexAM1_META1p1978 | MexAM1_META1p3063 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine phosphoribosyl transferase; Function of strongly homologous gene; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.940 |