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nadD nadD rsfS rsfS nadE nadE ACS40765.1 ACS40765.1 pncB pncB nadC nadC ppnK ppnK cobB-2 cobB-2 ACS42500.1 ACS42500.1 pntAA pntAA pntAB pntAB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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nadDProbable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (185 aa)    
Predicted Functional Partners:
rsfS
Conserved hypothetical protein, Iojap family protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
  
 0.970
nadE
NAD(+) synthase (glutamine-hydrolyzing) with a nitrilase-like domain; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.951
ACS40765.1
CinA (competence-damaged protein) family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the CinA family.
 
 
 0.948
pncB
Nicotinate phosphoribosyltransferase (NAPRTase); Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family.
  
 
 0.935
nadC
Nicotinate-mononucleotide pyrophosphorylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NadC/ModD family.
    
 0.932
ppnK
Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.930
cobB-2
NAD-dependent protein deacetylase, regulatory protein SIR2 family; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the sirtuin family. Class III subfamily.
   
 0.930
ACS42500.1
Putative nucleotide pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
     
 0.909
pntAA
NAD(P)+ transhydrogenase, subunit alpha part 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.908
pntAB
NAD(P) transhydrogenase, subunit alpha part 2; Function of strongly homologous gene; enzyme.
     
 0.908
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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