node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38066.1 | ACS40557.1 | MexAM1_META1p0099 | MexAM1_META1p2804 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | UvrD/REP helicase; Function of strongly homologous gene; enzyme. | 0.493 |
ACS38066.1 | uvrA | MexAM1_META1p0099 | MexAM1_META1p4267 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | DNA excision repair enzyme subunit, with UvrBC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.913 |
ACS38066.1 | uvrB | MexAM1_META1p0099 | MexAM1_META1p4445 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | UvrABC system protein B (UvrB protein) (Excinuclease ABC subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesi [...] | 0.988 |
ACS38066.1 | uvrC | MexAM1_META1p0099 | MexAM1_META1p3083 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | DNA exisiton repair enzyme together with UvrAB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.791 |
ACS38066.1 | uvrD | MexAM1_META1p0099 | MexAM1_META1p0214 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | DNA-dependent ATPase I and helicase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.543 |
ACS40557.1 | ACS38066.1 | MexAM1_META1p2804 | MexAM1_META1p0099 | UvrD/REP helicase; Function of strongly homologous gene; enzyme. | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | 0.493 |
ACS40557.1 | radA | MexAM1_META1p2804 | MexAM1_META1p4318 | UvrD/REP helicase; Function of strongly homologous gene; enzyme. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.662 |
ACS40557.1 | uvrA | MexAM1_META1p2804 | MexAM1_META1p4267 | UvrD/REP helicase; Function of strongly homologous gene; enzyme. | DNA excision repair enzyme subunit, with UvrBC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.475 |
ACS40557.1 | uvrB | MexAM1_META1p2804 | MexAM1_META1p4445 | UvrD/REP helicase; Function of strongly homologous gene; enzyme. | UvrABC system protein B (UvrB protein) (Excinuclease ABC subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesi [...] | 0.785 |
ACS40557.1 | uvrC | MexAM1_META1p2804 | MexAM1_META1p3083 | UvrD/REP helicase; Function of strongly homologous gene; enzyme. | DNA exisiton repair enzyme together with UvrAB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.654 |
ACS40557.1 | uvrD | MexAM1_META1p2804 | MexAM1_META1p0214 | UvrD/REP helicase; Function of strongly homologous gene; enzyme. | DNA-dependent ATPase I and helicase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.911 |
ACS41220.1 | uvrC | MexAM1_META1p3483 | MexAM1_META1p3083 | Hypothetical protein; No homology to any previously reported sequences. | DNA exisiton repair enzyme together with UvrAB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.744 |
moaD | pgsA | MexAM1_META1p3081 | MexAM1_META1p3082 | Molybdopterin converting factor, subunit 1; Function of strongly homologous gene; enzyme. | Phosphatidylglycerophosphate synthetase; Function of strongly homologous gene; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.696 |
moaD | uvrC | MexAM1_META1p3081 | MexAM1_META1p3083 | Molybdopterin converting factor, subunit 1; Function of strongly homologous gene; enzyme. | DNA exisiton repair enzyme together with UvrAB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.655 |
mutM | uvrC | MexAM1_META1p4436 | MexAM1_META1p3083 | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | DNA exisiton repair enzyme together with UvrAB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.813 |
pgsA | moaD | MexAM1_META1p3082 | MexAM1_META1p3081 | Phosphatidylglycerophosphate synthetase; Function of strongly homologous gene; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Molybdopterin converting factor, subunit 1; Function of strongly homologous gene; enzyme. | 0.696 |
pgsA | uvrC | MexAM1_META1p3082 | MexAM1_META1p3083 | Phosphatidylglycerophosphate synthetase; Function of strongly homologous gene; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | DNA exisiton repair enzyme together with UvrAB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.846 |
radA | ACS40557.1 | MexAM1_META1p4318 | MexAM1_META1p2804 | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | UvrD/REP helicase; Function of strongly homologous gene; enzyme. | 0.662 |
radA | uvrB | MexAM1_META1p4318 | MexAM1_META1p4445 | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | UvrABC system protein B (UvrB protein) (Excinuclease ABC subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesi [...] | 0.430 |
radA | uvrC | MexAM1_META1p4318 | MexAM1_META1p3083 | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | DNA exisiton repair enzyme together with UvrAB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.713 |