STRINGSTRING
nepR nepR phyR phyR ecfG1 ecfG1 rpoD rpoD ACS40516.1 ACS40516.1 hpt hpt ctaA ctaA osmC osmC ACS39139.1 ACS39139.1 ACS40465.1 ACS40465.1 rpoH rpoH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nepRAnti-sigma factor; Function experimentally demonstrated in the studied strain; factor. (82 aa)    
Predicted Functional Partners:
phyR
PhyR; Key regulator for adaptation to epiphytic life (leaf colonizing) of the bacterium. Positively regulates several genes including katE, sodA, hsp20, dps and gloA. However, it is not known whether this regulation is direct or indirect. Also induces several dehydrogenases.
   
 
 0.933
ecfG1
RNA polymerase sigma factor; Function experimentally demonstrated in the studied strain; factor.
   
 
 0.842
rpoD
Sigma D (sigma 70) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
      
 0.661
ACS40516.1
Sensor histidine kinase; Function of strongly homologous gene; regulator.
      
 0.660
hpt
Hypoxanthine phosphoribosyl transferase; Function of strongly homologous gene; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
      
 0.609
ctaA
Putative cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily.
      
 0.602
osmC
Osmotically inducible protein OsmC; Function of homologous gene experimentally demonstrated in an other organism; membrane component.
      
 0.532
ACS39139.1
Hypothetical protein; No homology to any previously reported sequences.
      
 0.530
ACS40465.1
Hypothetical protein; No homology to any previously reported sequences.
      
 0.530
rpoH
RNA polymerase sigma-32 (sigma H) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.
      
 0.449
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.