node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS42293.1 | guaB | MexAM1_META1p4665 | MexAM1_META1p3145 | Putative deaminase reductase domain-containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.476 |
ACS42293.1 | ribAB | MexAM1_META1p4665 | MexAM1_META1p3198 | Putative deaminase reductase domain-containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.922 |
ACS42293.1 | ribE | MexAM1_META1p4665 | MexAM1_META1p3375 | Putative deaminase reductase domain-containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.694 |
ACS42293.1 | ribE-2 | MexAM1_META1p4665 | MexAM1_META1p3380 | Putative deaminase reductase domain-containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Riboflavin synthase, alpha subunit; Function of strongly homologous gene; enzyme. | 0.856 |
cyaA | folE | MexAM1_META1p3294 | MexAM1_META1p2264 | Adenylate/guanylate cyclase; Function of strongly homologous gene; enzyme. | GTP cyclohydrolase I; Function of strongly homologous gene; enzyme. | 0.802 |
cyaA | moaA | MexAM1_META1p3294 | MexAM1_META1p2843 | Adenylate/guanylate cyclase; Function of strongly homologous gene; enzyme. | Molybdenum biosynthetic protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.844 |
cyaA | ribAB | MexAM1_META1p3294 | MexAM1_META1p3198 | Adenylate/guanylate cyclase; Function of strongly homologous gene; enzyme. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.879 |
folE | cyaA | MexAM1_META1p2264 | MexAM1_META1p3294 | GTP cyclohydrolase I; Function of strongly homologous gene; enzyme. | Adenylate/guanylate cyclase; Function of strongly homologous gene; enzyme. | 0.802 |
folE | guaB | MexAM1_META1p2264 | MexAM1_META1p3145 | GTP cyclohydrolase I; Function of strongly homologous gene; enzyme. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.422 |
folE | moaA | MexAM1_META1p2264 | MexAM1_META1p2843 | GTP cyclohydrolase I; Function of strongly homologous gene; enzyme. | Molybdenum biosynthetic protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.910 |
folE | ribAB | MexAM1_META1p2264 | MexAM1_META1p3198 | GTP cyclohydrolase I; Function of strongly homologous gene; enzyme. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.946 |
folE | ribD | MexAM1_META1p2264 | MexAM1_META1p3381 | GTP cyclohydrolase I; Function of strongly homologous gene; enzyme. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.502 |
guaB | ACS42293.1 | MexAM1_META1p3145 | MexAM1_META1p4665 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Putative deaminase reductase domain-containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.476 |
guaB | folE | MexAM1_META1p3145 | MexAM1_META1p2264 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GTP cyclohydrolase I; Function of strongly homologous gene; enzyme. | 0.422 |
guaB | ribAB | MexAM1_META1p3145 | MexAM1_META1p3198 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.919 |
guaB | ribD | MexAM1_META1p3145 | MexAM1_META1p3381 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.627 |
guaB | ribE | MexAM1_META1p3145 | MexAM1_META1p3375 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.916 |
guaB | rpsB | MexAM1_META1p3145 | MexAM1_META1p2057 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 30S ribosomal protein S2; Function of strongly homologous gene; structure; Belongs to the universal ribosomal protein uS2 family. | 0.862 |
moaA | cyaA | MexAM1_META1p2843 | MexAM1_META1p3294 | Molybdenum biosynthetic protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | Adenylate/guanylate cyclase; Function of strongly homologous gene; enzyme. | 0.844 |
moaA | folE | MexAM1_META1p2843 | MexAM1_META1p2264 | Molybdenum biosynthetic protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | GTP cyclohydrolase I; Function of strongly homologous gene; enzyme. | 0.910 |