node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38762.1 | nrdR | MexAM1_META1p0841 | MexAM1_META1p3382 | Putative biotin-protein ligase (birA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.418 |
ACS38762.1 | ribAB | MexAM1_META1p0841 | MexAM1_META1p3198 | Putative biotin-protein ligase (birA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.491 |
ACS38762.1 | ribD | MexAM1_META1p0841 | MexAM1_META1p3381 | Putative biotin-protein ligase (birA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.492 |
ACS39146.1 | nrdR | MexAM1_META1p1282 | MexAM1_META1p3382 | Conserved hypothetical protein (large extracellular alpha-helical protein); Homologs of previously reported genes of unknown function. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.485 |
ACS41120.1 | glyA | MexAM1_META1p3383 | MexAM1_META1p3384 | Putative transcriptional regulator, Rrf2 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.421 |
ACS41120.1 | nrdR | MexAM1_META1p3383 | MexAM1_META1p3382 | Putative transcriptional regulator, Rrf2 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.536 |
ACS41120.1 | ribD | MexAM1_META1p3383 | MexAM1_META1p3381 | Putative transcriptional regulator, Rrf2 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.570 |
ACS41120.1 | ribE-2 | MexAM1_META1p3383 | MexAM1_META1p3380 | Putative transcriptional regulator, Rrf2 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Riboflavin synthase, alpha subunit; Function of strongly homologous gene; enzyme. | 0.528 |
cmk | nrdR | MexAM1_META1p2119 | MexAM1_META1p3382 | Cytidine monophosphate (CMP) kinase; Function of strongly homologous gene; enzyme. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.698 |
cmk | nusB | MexAM1_META1p2119 | MexAM1_META1p3374 | Cytidine monophosphate (CMP) kinase; Function of strongly homologous gene; enzyme. | Transcription antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.403 |
glyA | ACS41120.1 | MexAM1_META1p3384 | MexAM1_META1p3383 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative transcriptional regulator, Rrf2 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | 0.421 |
glyA | nrdR | MexAM1_META1p3384 | MexAM1_META1p3382 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.458 |
glyA | ribAB | MexAM1_META1p3384 | MexAM1_META1p3198 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.610 |
glyA | ribD | MexAM1_META1p3384 | MexAM1_META1p3381 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.437 |
lexA | nrdR | MexAM1_META1p5132 | MexAM1_META1p3382 | SOS response transcriptional repressor, lexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.640 |
lexA | nusB | MexAM1_META1p5132 | MexAM1_META1p3374 | SOS response transcriptional repressor, lexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Transcription antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.420 |
nrdR | ACS38762.1 | MexAM1_META1p3382 | MexAM1_META1p0841 | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Putative biotin-protein ligase (birA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.418 |
nrdR | ACS39146.1 | MexAM1_META1p3382 | MexAM1_META1p1282 | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Conserved hypothetical protein (large extracellular alpha-helical protein); Homologs of previously reported genes of unknown function. | 0.485 |
nrdR | ACS41120.1 | MexAM1_META1p3382 | MexAM1_META1p3383 | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Putative transcriptional regulator, Rrf2 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | 0.536 |
nrdR | cmk | MexAM1_META1p3382 | MexAM1_META1p2119 | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Cytidine monophosphate (CMP) kinase; Function of strongly homologous gene; enzyme. | 0.698 |