STRINGSTRING
ccrfM ccrfM lexA lexA ACS42773.1 ACS42773.1 cobT-2 cobT-2 sucC sucC sucD sucD mtkA mtkA mtkB mtkB cobS-2 cobS-2 ACS41179.1 ACS41179.1 atpF atpF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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ccrfMSite-specific DNA-methyltransferase (adenine-specific); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the N(4)/N(6)-methyltransferase family. (398 aa)    
Predicted Functional Partners:
lexA
SOS response transcriptional repressor, lexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
    
 0.902
ACS42773.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
   
 0.736
cobT-2
Cobaltochelatase (cobT protein); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
     0.575
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
    0.572
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
    0.572
mtkA
Malate thiokinase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the succinate/malate CoA ligase beta subunit family.
   
    0.572
mtkB
Malate thiokinase, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
    0.572
cobS-2
Cobaltochelatase (cobS protein); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
    0.544
ACS41179.1
Putative chaperone protein, DnaJ domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor.
  
 
   0.483
atpF
Putative F0F1 ATP synthase, subunit b (atpF); Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family.
  
     0.478
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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