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coxA-2 coxA-2 ACS38081.1 ACS38081.1 ACS38083.1 ACS38083.1 coxC coxC coxB coxB petB petB cyoC cyoC coxE coxE cyoA cyoA nuoM nuoM nuoH nuoH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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coxA-2Cytochrome c oxidase subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (542 aa)    
Predicted Functional Partners:
ACS38081.1
Putative Cytochrome c oxidase, subunit II (coxB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.999
ACS38083.1
Putative Cytochrome c oxidase, subunit III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.999
coxC
Cytochrome c oxidase subunit III; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 0.999
coxB
Cytochrome c oxidase subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
 0.999
petB
Ubiquinol-cytochrome c reductase complex, cytochrome b subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
 
 0.991
cyoC
Cytochrome o ubiquinol oxidase, subunit III; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 0.987
coxE
Heme O synthase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
 
 
 0.979
cyoA
Cytochrome o ubiquinol oxidase subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.968
nuoM
NADH-quinone oxidoreductase chain M (NADH dehydrogenase I, chain M); Function of strongly homologous gene; enzyme.
  
 
 0.960
nuoH
NADH-quinone oxidoreductase subunit H (NADH dehydrogenase I subunit H); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
  
 
 0.959
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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