node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS41590.1 | ACS42730.1 | MexAM1_META1p3906 | MexAM1_META1p5126 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.677 |
ACS41590.1 | kdsB | MexAM1_META1p3906 | MexAM1_META1p0233 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.416 |
ACS41590.1 | kdsD | MexAM1_META1p3906 | MexAM1_META1p3866 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Arabinose-5-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.511 |
ACS41590.1 | lpxA | MexAM1_META1p3906 | MexAM1_META1p5125 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.710 |
ACS41590.1 | lpxB | MexAM1_META1p3906 | MexAM1_META1p5127 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.743 |
ACS41590.1 | lpxC | MexAM1_META1p3906 | MexAM1_META1p3155 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | UDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.696 |
ACS41590.1 | lpxK | MexAM1_META1p3906 | MexAM1_META1p3173 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.783 |
ACS41590.1 | lpxM | MexAM1_META1p3906 | MexAM1_META1p3702 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Lipid A biosynthesis lauroyl acyltransferase; Function of strongly homologous gene; enzyme. | 0.760 |
ACS41590.1 | waaA | MexAM1_META1p3906 | MexAM1_META1p3174 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 3-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.765 |
ACS42730.1 | ACS41590.1 | MexAM1_META1p5126 | MexAM1_META1p3906 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.677 |
ACS42730.1 | kdsB | MexAM1_META1p5126 | MexAM1_META1p0233 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.731 |
ACS42730.1 | kdsD | MexAM1_META1p5126 | MexAM1_META1p3866 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Arabinose-5-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.775 |
ACS42730.1 | lpxA | MexAM1_META1p5126 | MexAM1_META1p5125 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.954 |
ACS42730.1 | lpxB | MexAM1_META1p5126 | MexAM1_META1p5127 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.974 |
ACS42730.1 | lpxC | MexAM1_META1p5126 | MexAM1_META1p3155 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | UDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.806 |
ACS42730.1 | lpxK | MexAM1_META1p5126 | MexAM1_META1p3173 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.826 |
ACS42730.1 | lpxM | MexAM1_META1p5126 | MexAM1_META1p3702 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Lipid A biosynthesis lauroyl acyltransferase; Function of strongly homologous gene; enzyme. | 0.765 |
ACS42730.1 | waaA | MexAM1_META1p5126 | MexAM1_META1p3174 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 3-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.791 |
acpXL | lpxM | MexAM1_META1p4997 | MexAM1_META1p3702 | Specialized acyl carrier protein (ACP); Function of homologous gene experimentally demonstrated in an other organism; carrier. | Lipid A biosynthesis lauroyl acyltransferase; Function of strongly homologous gene; enzyme. | 0.816 |
kdsB | ACS41590.1 | MexAM1_META1p0233 | MexAM1_META1p3906 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.416 |