node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38222.1 | ACS41614.1 | MexAM1_META1p0262 | MexAM1_META1p3930 | Putative transcriptional regulator, AraC family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.554 |
ACS39663.1 | ACS41614.1 | MexAM1_META1p1821 | MexAM1_META1p3930 | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.426 |
ACS39663.1 | aroB | MexAM1_META1p1821 | MexAM1_META1p1535 | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.545 |
ACS39663.1 | ribD | MexAM1_META1p1821 | MexAM1_META1p3381 | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.518 |
ACS40866.1 | ACS41614.1 | MexAM1_META1p3118 | MexAM1_META1p3930 | Conserved hypothetical protein, DNA-binding and glycosylase domains; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.435 |
ACS41613.1 | ACS41614.1 | MexAM1_META1p3929 | MexAM1_META1p3930 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.427 |
ACS41614.1 | ACS38222.1 | MexAM1_META1p3930 | MexAM1_META1p0262 | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative transcriptional regulator, AraC family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | 0.554 |
ACS41614.1 | ACS39663.1 | MexAM1_META1p3930 | MexAM1_META1p1821 | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.426 |
ACS41614.1 | ACS40866.1 | MexAM1_META1p3930 | MexAM1_META1p3118 | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein, DNA-binding and glycosylase domains; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.435 |
ACS41614.1 | ACS41613.1 | MexAM1_META1p3930 | MexAM1_META1p3929 | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.427 |
ACS41614.1 | ACS42099.1 | MexAM1_META1p3930 | MexAM1_META1p4468 | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | VOC domain-containing protein; Homologs of previously reported genes of unknown function. | 0.404 |
ACS41614.1 | aroB | MexAM1_META1p3930 | MexAM1_META1p1535 | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.453 |
ACS41614.1 | ribD | MexAM1_META1p3930 | MexAM1_META1p3381 | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.423 |
ACS41614.1 | thyA | MexAM1_META1p3930 | MexAM1_META1p2853 | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.838 |
ACS42099.1 | ACS41614.1 | MexAM1_META1p4468 | MexAM1_META1p3930 | VOC domain-containing protein; Homologs of previously reported genes of unknown function. | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.404 |
aroB | ACS39663.1 | MexAM1_META1p1535 | MexAM1_META1p1821 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.545 |
aroB | ACS41614.1 | MexAM1_META1p1535 | MexAM1_META1p3930 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.453 |
aroB | thyA | MexAM1_META1p1535 | MexAM1_META1p2853 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.501 |
ribD | ACS39663.1 | MexAM1_META1p3381 | MexAM1_META1p1821 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.518 |
ribD | ACS41614.1 | MexAM1_META1p3381 | MexAM1_META1p3930 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Putative riboflavin biosynthesis protein RibD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.423 |