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proC proC putA putA proB proB arcB arcB proA proA ACS39331.1 ACS39331.1 ACS41792.1 ACS41792.1 ACS41794.1 ACS41794.1 rpoD rpoD aroB aroB argD argD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (277 aa)    
Predicted Functional Partners:
putA
Proline dehydrogenase PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
   
 0.954
proB
Glutamate 5-kinase (Gamma-glutamyl kinase) (GK); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 0.930
arcB
Ornithine cyclodeaminase (OCD); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 
 0.927
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 
 0.823
ACS39331.1
Putative enzyme with PLP-binding domain, putative alanine racemase; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
 0.793
ACS41792.1
Putative transcriptional regulator, TetR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
       0.625
ACS41794.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
       0.609
rpoD
Sigma D (sigma 70) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
     
 0.591
aroB
Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
 
   
 0.555
argD
Succinylornithine transaminase, also has acetylornitine transaminase activity, PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
  
 0.525
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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