node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS39850.1 | dnaA | MexAM1_META1p2048 | MexAM1_META1p0001 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.553 |
ACS39850.1 | dnaB | MexAM1_META1p2048 | MexAM1_META1p4320 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.772 |
ACS39850.1 | dnaX | MexAM1_META1p2048 | MexAM1_META1p1794 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | DNA polymerase III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.465 |
dnaA | ACS39850.1 | MexAM1_META1p0001 | MexAM1_META1p2048 | DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.553 |
dnaA | dnaB | MexAM1_META1p0001 | MexAM1_META1p4320 | DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.923 |
dnaA | dnaG | MexAM1_META1p0001 | MexAM1_META1p0436 | DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. | 0.531 |
dnaA | ftsK | MexAM1_META1p0001 | MexAM1_META1p2090 | DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA-binding membrane protein required for chromosome resolution and partitioning; Function of strongly homologous gene; cell process. | 0.753 |
dnaA | lepA | MexAM1_META1p0001 | MexAM1_META1p1025 | DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | GTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.465 |
dnaA | mfd | MexAM1_META1p0001 | MexAM1_META1p4552 | DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.582 |
dnaA | mfd-2 | MexAM1_META1p0001 | MexAM1_META1p1061 | DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DEAD/DEAH box helicase domain protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.630 |
dnaB | ACS39850.1 | MexAM1_META1p4320 | MexAM1_META1p2048 | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.772 |
dnaB | dnaA | MexAM1_META1p4320 | MexAM1_META1p0001 | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.923 |
dnaB | dnaG | MexAM1_META1p4320 | MexAM1_META1p0436 | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. | 0.965 |
dnaB | dnaX | MexAM1_META1p4320 | MexAM1_META1p1794 | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.767 |
dnaB | ftsK | MexAM1_META1p4320 | MexAM1_META1p2090 | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA-binding membrane protein required for chromosome resolution and partitioning; Function of strongly homologous gene; cell process. | 0.787 |
dnaB | holB | MexAM1_META1p4320 | MexAM1_META1p4581 | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, delta prime subunit; Function of strongly homologous gene; putative enzyme. | 0.833 |
dnaB | lepA | MexAM1_META1p4320 | MexAM1_META1p1025 | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | GTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.813 |
dnaB | mfd | MexAM1_META1p4320 | MexAM1_META1p4552 | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.766 |
dnaB | mfd-2 | MexAM1_META1p4320 | MexAM1_META1p1061 | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DEAD/DEAH box helicase domain protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.768 |
dnaB | rpoA | MexAM1_META1p4320 | MexAM1_META1p2167 | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.785 |