node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38886.1 | ACS41988.1 | MexAM1_META1p0991 | MexAM1_META1p4355 | Putative Galactose oxidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.445 |
ACS38886.1 | ACS41989.1 | MexAM1_META1p0991 | MexAM1_META1p4356 | Putative Galactose oxidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.539 |
ACS41987.1 | ACS41988.1 | MexAM1_META1p4354 | MexAM1_META1p4355 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.893 |
ACS41987.1 | ACS41989.1 | MexAM1_META1p4354 | MexAM1_META1p4356 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.881 |
ACS41988.1 | ACS38886.1 | MexAM1_META1p4355 | MexAM1_META1p0991 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative Galactose oxidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.445 |
ACS41988.1 | ACS41987.1 | MexAM1_META1p4355 | MexAM1_META1p4354 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.893 |
ACS41988.1 | ACS41989.1 | MexAM1_META1p4355 | MexAM1_META1p4356 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.948 |
ACS41989.1 | ACS38886.1 | MexAM1_META1p4356 | MexAM1_META1p0991 | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Putative Galactose oxidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.539 |
ACS41989.1 | ACS41987.1 | MexAM1_META1p4356 | MexAM1_META1p4354 | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.881 |
ACS41989.1 | ACS41988.1 | MexAM1_META1p4356 | MexAM1_META1p4355 | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.948 |
ACS41989.1 | aroB | MexAM1_META1p4356 | MexAM1_META1p1535 | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.478 |
ACS41989.1 | dme | MexAM1_META1p4356 | MexAM1_META1p0594 | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | NAD-dependent malic enzyme; Function of homologous gene experimentally demonstrated in an other organism; putative enzyme. | 0.506 |
ACS41989.1 | ispDF | MexAM1_META1p4356 | MexAM1_META1p3018 | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). | 0.469 |
ACS41989.1 | nadE | MexAM1_META1p4356 | MexAM1_META1p4425 | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | NAD(+) synthase (glutamine-hydrolyzing) with a nitrilase-like domain; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.475 |
ACS41989.1 | ribAB | MexAM1_META1p4356 | MexAM1_META1p3198 | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.437 |
ACS41989.1 | tly | MexAM1_META1p4356 | MexAM1_META1p4708 | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Hemolysin; Function of strongly homologous gene; enzyme. | 0.587 |
ACS41989.1 | yehL | MexAM1_META1p4356 | MexAM1_META1p1405 | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Putative ABC superfamily protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.483 |
aroB | ACS41989.1 | MexAM1_META1p1535 | MexAM1_META1p4356 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Conserved hypothetical protein with putative sugar kinase domain; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.478 |
aroB | ispDF | MexAM1_META1p1535 | MexAM1_META1p3018 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). | 0.508 |
aroB | nadE | MexAM1_META1p1535 | MexAM1_META1p4425 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | NAD(+) synthase (glutamine-hydrolyzing) with a nitrilase-like domain; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.425 |