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nadE nadE nadD nadD cobB-2 cobB-2 ppnK ppnK pntB pntB ACS42500.1 ACS42500.1 pntAA pntAA pntAB pntAB mazG mazG ACS39408.1 ACS39408.1 soxA-2 soxA-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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nadENAD(+) synthase (glutamine-hydrolyzing) with a nitrilase-like domain; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (682 aa)    
Predicted Functional Partners:
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.951
cobB-2
NAD-dependent protein deacetylase, regulatory protein SIR2 family; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the sirtuin family. Class III subfamily.
   
 0.947
ppnK
Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.945
pntB
NAD(P) transhydrogenase, subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.933
ACS42500.1
Putative nucleotide pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.917
pntAA
NAD(P)+ transhydrogenase, subunit alpha part 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.910
pntAB
NAD(P) transhydrogenase, subunit alpha part 2; Function of strongly homologous gene; enzyme.
     
 0.910
mazG
Nucleoside triphosphate pyrophosphohydrolase MazG; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
  0.900
ACS39408.1
Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.780
soxA-2
Sarcosine oxidase, alpha subunit; Function of strongly homologous gene; enzyme.
  
 
 0.780
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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