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metC metC metH metH cysK cysK cysK-2 cysK-2 sseA sseA metY-3 metY-3 metY metY metY-2 metY-2 metY-4 metY-4 ahcY ahcY ACS40808.1 ACS40808.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
metCCystathionine beta-lyase, PLP-dependent (beta-cystathionase); Function of strongly homologous gene; enzyme. (395 aa)    
Predicted Functional Partners:
metH
B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.986
cysK
Subunit of cysteine synthase A and O-acetylserine sulfhydrolase A, PLP-dependent enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 0.985
cysK-2
Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.983
sseA
3-mercaptopyruvate sulfurtransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.968
metY-3
Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
0.938
metY
Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
0.937
metY-2
Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase); Function of strongly homologous gene; enzyme.
 
 
0.937
metY-4
Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
0.937
ahcY
S-adenosyl L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 0.929
ACS40808.1
Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
  
 
0.926
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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