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ldhA ldhA dme dme pyk pyk pyk-2 pyk-2 pdhB pdhB ppdK ppdK gloB gloB ycbL ycbL pdhA pdhA poxB poxB leuA leuA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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ldhAFermentative D-lactate dehydrogenase, NAD-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (336 aa)    
Predicted Functional Partners:
dme
NAD-dependent malic enzyme; Function of homologous gene experimentally demonstrated in an other organism; putative enzyme.
   
 0.943
pyk
Pyruvate kinase; Function of strongly homologous gene; enzyme; Belongs to the pyruvate kinase family.
  
 0.927
pyk-2
Pyruvate kinase; Function of strongly homologous gene; enzyme.
  
 0.927
pdhB
Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 
 0.927
ppdK
Pyruvate phosphate dikinase (Pyruvate, orthophosphate dikinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the PEP-utilizing enzyme family.
    
 0.916
gloB
Putative hydroxyacylglutathione hydrolase (gloB-like) with metallo-hydrolase/oxidoreductase domain; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.
   
 0.904
ycbL
Putative metal-binding hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
   
 0.904
pdhA
Pyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.903
poxB
poxB; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TPP enzyme family.
   
 
 0.901
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 
 0.827
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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