node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
glyA | ilvA | MexAM1_META1p3384 | MexAM1_META1p3241 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.924 |
glyA | trpA | MexAM1_META1p3384 | MexAM1_META1p4890 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.932 |
glyA | trpB | MexAM1_META1p3384 | MexAM1_META1p0049 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.924 |
ilvA | glyA | MexAM1_META1p3241 | MexAM1_META1p3384 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
ilvA | trpA | MexAM1_META1p3241 | MexAM1_META1p4890 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.929 |
ilvA | trpB | MexAM1_META1p3241 | MexAM1_META1p0049 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.942 |
pabA | pabB | MexAM1_META1p4283 | MexAM1_META1p4284 | Aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex; Function of strongly homologous gene; enzyme. | Para-aminobenzoate synthase component I (ADC synthase); Function experimentally demonstrated in the studied strain; enzyme. | 0.999 |
pabA | trpA | MexAM1_META1p4283 | MexAM1_META1p4890 | Aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex; Function of strongly homologous gene; enzyme. | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.966 |
pabA | trpB | MexAM1_META1p4283 | MexAM1_META1p0049 | Aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex; Function of strongly homologous gene; enzyme. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.956 |
pabA | trpC | MexAM1_META1p4283 | MexAM1_META1p5121 | Aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex; Function of strongly homologous gene; enzyme. | Indole-3-glycerol phosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. | 0.996 |
pabA | trpD | MexAM1_META1p4283 | MexAM1_META1p5120 | Aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex; Function of strongly homologous gene; enzyme. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.998 |
pabA | trpE | MexAM1_META1p4283 | MexAM1_META1p5117 | Aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex; Function of strongly homologous gene; enzyme. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.999 |
pabA | trpF | MexAM1_META1p4283 | MexAM1_META1p0050 | Aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex; Function of strongly homologous gene; enzyme. | Putative phosphoribosylanthranilate isomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the TrpF family. | 0.963 |
pabA | trpG | MexAM1_META1p4283 | MexAM1_META1p5119 | Aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex; Function of strongly homologous gene; enzyme. | Aminodeoxychorismate synthase component II, Glutamine amido-transferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.810 |
pabB | pabA | MexAM1_META1p4284 | MexAM1_META1p4283 | Para-aminobenzoate synthase component I (ADC synthase); Function experimentally demonstrated in the studied strain; enzyme. | Aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex; Function of strongly homologous gene; enzyme. | 0.999 |
pabB | trpA | MexAM1_META1p4284 | MexAM1_META1p4890 | Para-aminobenzoate synthase component I (ADC synthase); Function experimentally demonstrated in the studied strain; enzyme. | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.986 |
pabB | trpB | MexAM1_META1p4284 | MexAM1_META1p0049 | Para-aminobenzoate synthase component I (ADC synthase); Function experimentally demonstrated in the studied strain; enzyme. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.958 |
pabB | trpC | MexAM1_META1p4284 | MexAM1_META1p5121 | Para-aminobenzoate synthase component I (ADC synthase); Function experimentally demonstrated in the studied strain; enzyme. | Indole-3-glycerol phosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. | 0.990 |
pabB | trpD | MexAM1_META1p4284 | MexAM1_META1p5120 | Para-aminobenzoate synthase component I (ADC synthase); Function experimentally demonstrated in the studied strain; enzyme. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.994 |
pabB | trpE | MexAM1_META1p4284 | MexAM1_META1p5117 | Para-aminobenzoate synthase component I (ADC synthase); Function experimentally demonstrated in the studied strain; enzyme. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.836 |