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thiD thiD ACS42507.1 ACS42507.1 thiE-2 thiE-2 thiE thiE thiC thiC ACS40154.1 ACS40154.1 thiG thiG thiS thiS rhlE rhlE moeB moeB ACS40459.1 ACS40459.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
thiDBifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); Function of strongly homologous gene; enzyme. (268 aa)    
Predicted Functional Partners:
ACS42507.1
Putative transcriptional activator (TenA family); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
 
 0.999
thiE-2
Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiE
Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
 
 0.998
thiC
Thiamine biosynthesis protein thiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
 0.993
ACS40154.1
Thiamine-phosphate pyrophosphorylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.982
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.933
thiS
Thiamin biosynthesis proteinsulfur carrier) ThiS; Function of strongly homologous gene; factor.
  
    0.844
rhlE
RNA helicase; Function of strongly homologous gene; enzyme.
 
 
   0.816
moeB
Molybdopterin synthase sulfurylase; Function of strongly homologous gene; enzyme.
  
 0.808
ACS40459.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
  
 0.731
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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