node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38322.1 | ACS42704.1 | MexAM1_META1p0374 | MexAM1_META1p5100 | Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.905 |
ACS38322.1 | gcvP | MexAM1_META1p0374 | MexAM1_META1p0620 | Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.938 |
ACS38322.1 | glyA | MexAM1_META1p0374 | MexAM1_META1p3384 | Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.914 |
ACS38322.1 | hemA | MexAM1_META1p0374 | MexAM1_META1p1968 | Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 5-aminolevulinic acid synthase (ALAS); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.929 |
ACS38322.1 | sga | MexAM1_META1p0374 | MexAM1_META1p1726 | Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine-glyoxylate aminotransferase (SGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.902 |
ACS38322.1 | sga-2 | MexAM1_META1p0374 | MexAM1_META1p4592 | Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine-glyoxylate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.902 |
ACS38322.1 | soxA-2 | MexAM1_META1p0374 | MexAM1_META1p4110 | Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Sarcosine oxidase, alpha subunit; Function of strongly homologous gene; enzyme. | 0.931 |
ACS38322.1 | soxD-2 | MexAM1_META1p0374 | MexAM1_META1p4109 | Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Sarcosine oxidase, delta subunit; Function of strongly homologous gene; enzyme. | 0.900 |
ACS42704.1 | ACS38322.1 | MexAM1_META1p5100 | MexAM1_META1p0374 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.905 |
ACS42704.1 | gcvP | MexAM1_META1p5100 | MexAM1_META1p0620 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.946 |
ACS42704.1 | glyA | MexAM1_META1p5100 | MexAM1_META1p3384 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.925 |
ACS42704.1 | hemA | MexAM1_META1p5100 | MexAM1_META1p1968 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 5-aminolevulinic acid synthase (ALAS); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.905 |
ACS42704.1 | ilvA | MexAM1_META1p5100 | MexAM1_META1p3241 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.921 |
ACS42704.1 | sga | MexAM1_META1p5100 | MexAM1_META1p1726 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine-glyoxylate aminotransferase (SGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.919 |
ACS42704.1 | sga-2 | MexAM1_META1p5100 | MexAM1_META1p4592 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine-glyoxylate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.919 |
ACS42704.1 | soxA-2 | MexAM1_META1p5100 | MexAM1_META1p4110 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Sarcosine oxidase, alpha subunit; Function of strongly homologous gene; enzyme. | 0.921 |
ACS42704.1 | soxD-2 | MexAM1_META1p5100 | MexAM1_META1p4109 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Sarcosine oxidase, delta subunit; Function of strongly homologous gene; enzyme. | 0.905 |
ACS42704.1 | thrC | MexAM1_META1p5100 | MexAM1_META1p3465 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Threonine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.927 |
gcvP | ACS38322.1 | MexAM1_META1p0620 | MexAM1_META1p0374 | Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.938 |
gcvP | ACS42704.1 | MexAM1_META1p0620 | MexAM1_META1p5100 | Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.946 |