node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dcd | mazG | MexAM1_META1p0286 | MexAM1_META1p4291 | 2'-deoxycytidine 5'-triphosphate deaminase; Function of strongly homologous gene; putative enzyme. | Nucleoside triphosphate pyrophosphohydrolase MazG; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.920 |
dcd | pyrG | MexAM1_META1p0286 | MexAM1_META1p5110 | 2'-deoxycytidine 5'-triphosphate deaminase; Function of strongly homologous gene; putative enzyme. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.931 |
guaA | guaB | MexAM1_META1p3135 | MexAM1_META1p3145 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.998 |
guaA | mazG | MexAM1_META1p3135 | MexAM1_META1p4291 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Nucleoside triphosphate pyrophosphohydrolase MazG; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.904 |
guaA | pyrG | MexAM1_META1p3135 | MexAM1_META1p5110 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.935 |
guaA | rplA | MexAM1_META1p3135 | MexAM1_META1p4386 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 50S ribosomal subunit protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.918 |
guaA | rplE | MexAM1_META1p3135 | MexAM1_META1p2180 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 50S ribosomal subunit protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. | 0.583 |
guaA | rplF | MexAM1_META1p3135 | MexAM1_META1p2177 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 50S ribosomal subunit protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. | 0.512 |
guaA | rplM | MexAM1_META1p3135 | MexAM1_META1p2739 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.879 |
guaA | rpoB | MexAM1_META1p3135 | MexAM1_META1p4405 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.927 |
guaA | rpsB | MexAM1_META1p3135 | MexAM1_META1p2057 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S2; Function of strongly homologous gene; structure; Belongs to the universal ribosomal protein uS2 family. | 0.734 |
guaB | guaA | MexAM1_META1p3145 | MexAM1_META1p3135 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.998 |
guaB | pyrG | MexAM1_META1p3145 | MexAM1_META1p5110 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.903 |
guaB | rplA | MexAM1_META1p3145 | MexAM1_META1p4386 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 50S ribosomal subunit protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.668 |
guaB | rplE | MexAM1_META1p3145 | MexAM1_META1p2180 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 50S ribosomal subunit protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. | 0.650 |
guaB | rplF | MexAM1_META1p3145 | MexAM1_META1p2177 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 50S ribosomal subunit protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. | 0.653 |
guaB | rplM | MexAM1_META1p3145 | MexAM1_META1p2739 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.714 |
guaB | rpoB | MexAM1_META1p3145 | MexAM1_META1p4405 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.902 |
guaB | rpsB | MexAM1_META1p3145 | MexAM1_META1p2057 | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 30S ribosomal protein S2; Function of strongly homologous gene; structure; Belongs to the universal ribosomal protein uS2 family. | 0.862 |
mazG | dcd | MexAM1_META1p4291 | MexAM1_META1p0286 | Nucleoside triphosphate pyrophosphohydrolase MazG; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 2'-deoxycytidine 5'-triphosphate deaminase; Function of strongly homologous gene; putative enzyme. | 0.920 |