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trpD trpD trpE trpE trpG trpG trpC trpC pabA pabA trpF trpF pabB pabB trpB trpB trpA trpA hisC hisC cobC cobC
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa)    
Predicted Functional Partners:
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 0.999
trpG
Aminodeoxychorismate synthase component II, Glutamine amido-transferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.999
trpC
Indole-3-glycerol phosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family.
  
 0.999
pabA
Aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex; Function of strongly homologous gene; enzyme.
 
 0.998
trpF
Putative phosphoribosylanthranilate isomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the TrpF family.
 
 
 0.997
pabB
Para-aminobenzoate synthase component I (ADC synthase); Function experimentally demonstrated in the studied strain; enzyme.
 
 0.994
trpB
Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.981
trpA
Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
 0.980
hisC
Histidinol-phosphate aminotransferase; Function of strongly homologous gene; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 0.812
cobC
Threonine-phosphate decarboxylase (L-threonine-O-3- phosphate decarboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
  
 0.812
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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