node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS40601.1 | glyA | MexAM1_META1p2848 | MexAM1_META1p3384 | Putative phosphoserine phosphatase (serB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
ACS40601.1 | ilvA | MexAM1_META1p2848 | MexAM1_META1p3241 | Putative phosphoserine phosphatase (serB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.921 |
ACS40601.1 | pssA | MexAM1_META1p2848 | MexAM1_META1p5192 | Putative phosphoserine phosphatase (serB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Phosphatidylserine synthase (pssA-like); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.910 |
ACS40601.1 | sdaB | MexAM1_META1p2848 | MexAM1_META1p4112 | Putative phosphoserine phosphatase (serB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | L-serine deaminase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.922 |
ACS40601.1 | sga | MexAM1_META1p2848 | MexAM1_META1p1726 | Putative phosphoserine phosphatase (serB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine-glyoxylate aminotransferase (SGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.930 |
ACS40601.1 | sga-2 | MexAM1_META1p2848 | MexAM1_META1p4592 | Putative phosphoserine phosphatase (serB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine-glyoxylate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.930 |
ACS40601.1 | trpB | MexAM1_META1p2848 | MexAM1_META1p0049 | Putative phosphoserine phosphatase (serB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.927 |
cdsA | pgsA | MexAM1_META1p2069 | MexAM1_META1p3082 | CDP-diglyceride synthase; Function of strongly homologous gene; enzyme; Belongs to the CDS family. | Phosphatidylglycerophosphate synthetase; Function of strongly homologous gene; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.952 |
cdsA | pssA | MexAM1_META1p2069 | MexAM1_META1p5192 | CDP-diglyceride synthase; Function of strongly homologous gene; enzyme; Belongs to the CDS family. | Phosphatidylserine synthase (pssA-like); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.932 |
glyA | ACS40601.1 | MexAM1_META1p3384 | MexAM1_META1p2848 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative phosphoserine phosphatase (serB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.937 |
glyA | ilvA | MexAM1_META1p3384 | MexAM1_META1p3241 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.924 |
glyA | pssA | MexAM1_META1p3384 | MexAM1_META1p5192 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphatidylserine synthase (pssA-like); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
glyA | sdaB | MexAM1_META1p3384 | MexAM1_META1p4112 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine deaminase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.969 |
glyA | sga | MexAM1_META1p3384 | MexAM1_META1p1726 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine-glyoxylate aminotransferase (SGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.959 |
glyA | sga-2 | MexAM1_META1p3384 | MexAM1_META1p4592 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine-glyoxylate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.956 |
glyA | trpB | MexAM1_META1p3384 | MexAM1_META1p0049 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.924 |
ilvA | ACS40601.1 | MexAM1_META1p3241 | MexAM1_META1p2848 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Putative phosphoserine phosphatase (serB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.921 |
ilvA | glyA | MexAM1_META1p3241 | MexAM1_META1p3384 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
ilvA | pssA | MexAM1_META1p3241 | MexAM1_META1p5192 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Phosphatidylserine synthase (pssA-like); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.901 |
ilvA | sdaB | MexAM1_META1p3241 | MexAM1_META1p4112 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-serine deaminase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.935 |