node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38130.1 | clpA | MexAM1_META1p0167 | MexAM1_META1p5259 | Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor. | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | 0.945 |
ACS38130.1 | clpP | MexAM1_META1p0167 | MexAM1_META1p2419 | Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor. | ATP-dependent Clp protease proteolytic subunit (Endopeptidase Clp); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.826 |
ACS38130.1 | dnaJ | MexAM1_META1p0167 | MexAM1_META1p3165 | Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.956 |
ACS38130.1 | ftsH | MexAM1_META1p0167 | MexAM1_META1p5299 | Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor. | Cell division protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.433 |
ACS38130.1 | grpE | MexAM1_META1p0167 | MexAM1_META1p0230 | Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor. | Putative heat shock protein (HSP-70 COFACTOR), grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction c [...] | 0.962 |
ACS38130.1 | htpG | MexAM1_META1p0167 | MexAM1_META1p0793 | Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor. | Chaperone Hsp90, heat shock protein C 62.5; Molecular chaperone. Has ATPase activity. | 0.973 |
ACS38130.1 | ibpA-2 | MexAM1_META1p0167 | MexAM1_META1p4658 | Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor. | Small heat shock protein; Function of strongly homologous gene; factor; Belongs to the small heat shock protein (HSP20) family. | 0.477 |
ACS38130.1 | lon | MexAM1_META1p0167 | MexAM1_META1p2421 | Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor. | ATP-dependent protease La (Lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.785 |
clpA | ACS38130.1 | MexAM1_META1p5259 | MexAM1_META1p0167 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor. | 0.945 |
clpA | clpP | MexAM1_META1p5259 | MexAM1_META1p2419 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit (Endopeptidase Clp); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.967 |
clpA | clpS | MexAM1_META1p5259 | MexAM1_META1p5258 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease adaptor protein clpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.993 |
clpA | dnaJ | MexAM1_META1p5259 | MexAM1_META1p3165 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.860 |
clpA | dnaK | MexAM1_META1p5259 | MexAM1_META1p3164 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.959 |
clpA | ftsH | MexAM1_META1p5259 | MexAM1_META1p5299 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | Cell division protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.819 |
clpA | grpE | MexAM1_META1p5259 | MexAM1_META1p0230 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | Putative heat shock protein (HSP-70 COFACTOR), grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction c [...] | 0.871 |
clpA | htpG | MexAM1_META1p5259 | MexAM1_META1p0793 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | Chaperone Hsp90, heat shock protein C 62.5; Molecular chaperone. Has ATPase activity. | 0.850 |
clpA | ibpA-2 | MexAM1_META1p5259 | MexAM1_META1p4658 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | Small heat shock protein; Function of strongly homologous gene; factor; Belongs to the small heat shock protein (HSP20) family. | 0.797 |
clpA | lon | MexAM1_META1p5259 | MexAM1_META1p2421 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | ATP-dependent protease La (Lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.824 |
clpP | ACS38130.1 | MexAM1_META1p2419 | MexAM1_META1p0167 | ATP-dependent Clp protease proteolytic subunit (Endopeptidase Clp); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor. | 0.826 |
clpP | clpA | MexAM1_META1p2419 | MexAM1_META1p5259 | ATP-dependent Clp protease proteolytic subunit (Endopeptidase Clp); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | 0.967 |