STRINGSTRING
ftsH ftsH hflK hflK folE folE hflC hflC clpX clpX ACS41067.1 ACS41067.1 ACS41988.1 ACS41988.1 rrmJ rrmJ hpt hpt rpsA rpsA rplB rplB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ftsHCell division protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (642 aa)    
Predicted Functional Partners:
hflK
Protease subunit hflK; HflC and HflK could encode or regulate a protease.
  
 0.979
folE
GTP cyclohydrolase I; Function of strongly homologous gene; enzyme.
 
  
 0.969
hflC
HflC protein precursor, modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK could regulate a protease.
  
 0.915
clpX
ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 
 
  
 0.888
ACS41067.1
Putative integral membrane protein, putative Band 7 protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component.
   
 0.880
ACS41988.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
   
 0.878
rrmJ
Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
 
  
 0.876
hpt
Hypoxanthine phosphoribosyl transferase; Function of strongly homologous gene; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.869
rpsA
30S ribosomal subunit protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
  
   0.853
rplB
50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
  
 
 0.842
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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