STRINGSTRING
exo-1 exo-1 dna-2 dna-2 mlh-1 mlh-1 msh-6 msh-6 pms-2 pms-2 him-6 him-6 rad-51 rad-51 wrn-1 wrn-1 mus-81 mus-81 msh-2 msh-2 mre-11 mre-11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
exo-1EXOnuclease. (639 aa)    
Predicted Functional Partners:
dna-2
Yeast DNA helicase/endonuclease family.
   
 
 0.998
mlh-1
DNA_mis_repair domain-containing protein.
   
 0.998
msh-6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
   
 0.996
pms-2
PMS (Post Meiotic Segregation) family.
   
 0.992
him-6
Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily.
  
 
 0.992
rad-51
DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA.
  
 
 0.991
wrn-1
Probable Werner syndrome ATP-dependent helicase homolog 1; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity).
  
 
 0.987
mus-81
ERCC4 domain-containing protein.
   
 
 0.986
msh-2
DNA_MISMATCH_REPAIR_2 domain-containing protein.
   
 
 0.986
mre-11
Double-strand break repair protein mre-11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites. Belongs to the MRE11/RAD32 family.
  
 
 0.979
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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