Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Blm | Brca2 | FBpp0081910 | FBpp0072209 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | 0.794 |
| Blm | DNAlig4 | FBpp0081910 | FBpp0073678 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | 0.764 |
| Blm | Ku80 | FBpp0081910 | FBpp0080322 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | 0.909 |
| Blm | Rad51D | FBpp0081910 | FBpp0290742 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Rad51 recombinase D (Rad51D) encodes a spn-A paralog involved in homologous recombination in the repair of double-strand breaks. It is likely important for regulating the product of spn-A. | 0.890 |
| Blm | mus81 | FBpp0081910 | FBpp0070165 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | EG:BACR7A4.16 protein; Mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair. | 0.988 |
| Blm | okr | FBpp0081910 | FBpp0077357 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | DNA repair and recombination protein RAD54-like; Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54. | 0.949 |
| Blm | spn-A | FBpp0081910 | FBpp0084955 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | DNA repair protein Rad51 homolog; Spindle A (spn-A) encodes a protein that forms a filament on single-stranded DNA, does a homology search of double-stranded DNA, and catalyzes strand exchange, swapping the single-strand DNA in and displacing the partner of the complementary strand. | 0.992 |
| Blm | spn-B | FBpp0081910 | FBpp0082392 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Spindle B (spn-B) encodes a member of the recA family. It is involved in double strand break repair in mitosis and meiosis. | 0.969 |
| Blm | spn-D | FBpp0081910 | FBpp0084486 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Spindle D (spn-D) encodes a DNA repair protein required for homologous recombinational DNA repair. It functions in meiotic recombination. | 0.858 |
| Blm | tos | FBpp0081910 | FBpp0080675 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). | 0.982 |
| Brca2 | Blm | FBpp0072209 | FBpp0081910 | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | 0.794 |
| Brca2 | DNAlig4 | FBpp0072209 | FBpp0073678 | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | 0.906 |
| Brca2 | Ku80 | FBpp0072209 | FBpp0080322 | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | 0.872 |
| Brca2 | Rad51D | FBpp0072209 | FBpp0290742 | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | Rad51 recombinase D (Rad51D) encodes a spn-A paralog involved in homologous recombination in the repair of double-strand breaks. It is likely important for regulating the product of spn-A. | 0.992 |
| Brca2 | mus81 | FBpp0072209 | FBpp0070165 | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | EG:BACR7A4.16 protein; Mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair. | 0.861 |
| Brca2 | okr | FBpp0072209 | FBpp0077357 | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | DNA repair and recombination protein RAD54-like; Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54. | 0.900 |
| Brca2 | spn-A | FBpp0072209 | FBpp0084955 | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | DNA repair protein Rad51 homolog; Spindle A (spn-A) encodes a protein that forms a filament on single-stranded DNA, does a homology search of double-stranded DNA, and catalyzes strand exchange, swapping the single-strand DNA in and displacing the partner of the complementary strand. | 0.999 |
| Brca2 | spn-B | FBpp0072209 | FBpp0082392 | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | Spindle B (spn-B) encodes a member of the recA family. It is involved in double strand break repair in mitosis and meiosis. | 0.994 |
| Brca2 | spn-D | FBpp0072209 | FBpp0084486 | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | Spindle D (spn-D) encodes a DNA repair protein required for homologous recombinational DNA repair. It functions in meiotic recombination. | 0.990 |
| Brca2 | tos | FBpp0072209 | FBpp0080675 | Breast cancer type 2 susceptibility protein homolog; BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). | 0.945 |
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