node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C18orf25 | VCPIP1 | ENSP00000481626 | ENSP00000309031 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | Deubiquitinating protein VCIP135; Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. | 0.618 |
C18orf25 | ZBTB11 | ENSP00000481626 | ENSP00000326200 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | 0.466 |
CGGBP1 | ZBTB11 | ENSP00000381429 | ENSP00000326200 | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | 0.470 |
CGGBP1 | ZNF654 | ENSP00000381429 | ENSP00000490842 | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. | Zinc finger protein 654; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.670 |
EDRF1 | ZBTB11 | ENSP00000349244 | ENSP00000326200 | Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene. | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | 0.452 |
PLEKHA4 | ZBTB11 | ENSP00000263265 | ENSP00000326200 | Pleckstrin homology domain-containing family A member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | 0.535 |
RPF1 | ZBTB11 | ENSP00000359688 | ENSP00000326200 | Ribosome production factor 1; May be required for ribosome biogenesis. | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | 0.689 |
SCAF8 | ZBTB11 | ENSP00000413098 | ENSP00000326200 | SR-related and CTD-associated factor 8; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...] | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | 0.459 |
SRSF11 | ZBTB11 | ENSP00000359988 | ENSP00000326200 | Serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing. | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | 0.457 |
STAG1 | ZBTB11 | ENSP00000372689 | ENSP00000326200 | Cohesin subunit SA-1; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | 0.497 |
VCPIP1 | C18orf25 | ENSP00000309031 | ENSP00000481626 | Deubiquitinating protein VCIP135; Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | 0.618 |
VCPIP1 | ZBTB11 | ENSP00000309031 | ENSP00000326200 | Deubiquitinating protein VCIP135; Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | 0.542 |
ZBTB11 | C18orf25 | ENSP00000326200 | ENSP00000481626 | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | 0.466 |
ZBTB11 | CGGBP1 | ENSP00000326200 | ENSP00000381429 | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. | 0.470 |
ZBTB11 | EDRF1 | ENSP00000326200 | ENSP00000349244 | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene. | 0.452 |
ZBTB11 | PLEKHA4 | ENSP00000326200 | ENSP00000263265 | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | Pleckstrin homology domain-containing family A member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. | 0.535 |
ZBTB11 | RPF1 | ENSP00000326200 | ENSP00000359688 | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | Ribosome production factor 1; May be required for ribosome biogenesis. | 0.689 |
ZBTB11 | SCAF8 | ENSP00000326200 | ENSP00000413098 | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | SR-related and CTD-associated factor 8; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...] | 0.459 |
ZBTB11 | SRSF11 | ENSP00000326200 | ENSP00000359988 | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | Serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing. | 0.457 |
ZBTB11 | STAG1 | ENSP00000326200 | ENSP00000372689 | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation. | Cohesin subunit SA-1; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. | 0.497 |