INSR protein (Homo sapiens) - STRING network view

STRING 9.05

INSR protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	INSR	insulin receptor; This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed-12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a hig [...] (1382 aa)
		(Homo sapiens)
Predicted Functional Partners:
	IRS1	insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. [...] (1242 aa)	•	•	•	0.999
	PTPN1	protein tyrosine phosphatase, non-receptor type 1; May play an important role in CKII- and p60c [...] (435 aa)	•	•	•	0.999
	GRB10	growth factor receptor-bound protein 10; Plays a functional role in insulin and IGF-I signaling [...] (594 aa)	•	•	•	0.999
	GRB14	growth factor receptor-bound protein 14; Interacts with the cytoplasmic domain of the autophosp [...] (540 aa)	•	•	•	0.999
	IRS2	insulin receptor substrate 2; May mediate the control of various cellular processes by insulin (1338 aa)	•	•	•	0.999
	INS	insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)	•	•	•	0.999
	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) pr [...] (724 aa)	•	•	•	0.999
	PTPN11	protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cyt [...] (593 aa)	•	•	•	0.999
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1; Signaling adapter that couples a [...] (584 aa)	•	•	•	0.999
	IGF1	insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from pl [...] (195 aa)	•	•	•	0.997

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Co-expression Experiments Databases Textmining

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