INSR protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

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insulin receptor; This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed-12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a hig [...] (1382 aa)
(Homo sapiens)
Predicted Functional Partners:
insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. [...] (1242 aa)
protein tyrosine phosphatase, non-receptor type 1; May play an important role in CKII- and p60c [...] (435 aa)
growth factor receptor-bound protein 10; Plays a functional role in insulin and IGF-I signaling [...] (594 aa)
growth factor receptor-bound protein 14; Interacts with the cytoplasmic domain of the autophosp [...] (540 aa)
insulin receptor substrate 2; May mediate the control of various cellular processes by insulin (1338 aa)
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) pr [...] (724 aa)
protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cyt [...] (593 aa)
SHC (Src homology 2 domain containing) transforming protein 1; Signaling adapter that couples a [...] (584 aa)
insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from pl [...] (195 aa)
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