node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cdc1 | cdc20 | P87324 | P87154 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.950 |
cdc1 | cdc27 | P87324 | P30261 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | DNA polymerase delta subunit 3. | 0.999 |
cdc1 | cdc6 | P87324 | P30316 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | DNA polymerase delta catalytic subunit; Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Belongs to the DNA polymerase type-B family. | 0.999 |
cdc1 | cdm1 | P87324 | O59835 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | DNA polymerase delta subunit 4; Appears to have a role in the stabilization of the DNA polymerase delta complex. | 0.999 |
cdc1 | dpb2 | P87324 | O94263 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | DNA polymerase epsilon subunit B; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. Belongs to the DNA polymerase epsilon subunit B family. | 0.859 |
cdc1 | mcm2 | P87324 | P40377 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | DNA replication licensing factor mcm2; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.772 |
cdc1 | pcn1 | P87324 | Q03392 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.986 |
cdc1 | rad2 | P87324 | P39750 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.937 |
cdc1 | ssb1 | P87324 | Q92372 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | Replication factor A protein 1; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism; Belongs to the replication factor A protein 1 family. | 0.927 |
cdc20 | cdc1 | P87154 | P87324 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | 0.950 |
cdc20 | cdc27 | P87154 | P30261 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA polymerase delta subunit 3. | 0.840 |
cdc20 | cdc6 | P87154 | P30316 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA polymerase delta catalytic subunit; Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Belongs to the DNA polymerase type-B family. | 0.996 |
cdc20 | cdm1 | P87154 | O59835 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA polymerase delta subunit 4; Appears to have a role in the stabilization of the DNA polymerase delta complex. | 0.802 |
cdc20 | cdt1 | P87154 | P40382 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | Cell division cycle protein cdt1; DNA replication licensing factor, required for pre- replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM helicase complex to the replication origins; Belongs to the Cdt1 family. | 0.722 |
cdc20 | dpb2 | P87154 | O94263 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA polymerase epsilon subunit B; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. Belongs to the DNA polymerase epsilon subunit B family. | 0.999 |
cdc20 | mcm2 | P87154 | P40377 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA replication licensing factor mcm2; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.998 |
cdc20 | pcn1 | P87154 | Q03392 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.963 |
cdc20 | rad2 | P87154 | P39750 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.878 |
cdc20 | ssb1 | P87154 | Q92372 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | Replication factor A protein 1; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism; Belongs to the replication factor A protein 1 family. | 0.645 |
cdc27 | cdc1 | P30261 | P87324 | DNA polymerase delta subunit 3. | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. | 0.999 |