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nrdA nrdA nrdB nrdB tmk tmk nrdJa nrdJa nrdJb nrdJb ndk ndk adk adk cmk cmk gmk gmk algH algH pykA pykA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
nrdANrdA, catalytic component of class Ia ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (963 aa)    
Predicted Functional Partners:
nrdB
NrdB, tyrosyl radical-harboring component of class Ia ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
 
 0.999
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.972
nrdJa
NrdJa; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
0.949
nrdJb
NrdJb; Class II (cobalamin-dependent) ribonucleotide-diphosphate reductase subunit, NrdJb.
 
  
 0.943
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. The 12-kDa membrane-associated form synthesizes GTP in preference to other nucleoside triphosphates. Important for alginate synthesis; Belongs to the NDK family.
  
 
 0.939
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
 
 0.936
cmk
Cytidylate kinase; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 
 0.923
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.921
algH
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); Belongs to the UPF0301 (AlgH) family.
   
 0.909
pykA
Pyruvate kinase II; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the pyruvate kinase family.
  
 
 0.906
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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