STRINGSTRING
PA1168 PA1168 loxA loxA PA3886 PA3886 PA4140 PA4140 PA4139 PA4139 tadA tadA PA4624 PA4624 PA4625 PA4625 PA2204 PA2204 flp flp armR armR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PA1168Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (106 aa)    
Predicted Functional Partners:
loxA
Probable lipoxygenase; Exhibits lipoxin synthase activity as part of a bacterial evasion strategy to suppress the host immune defense. Oxygenates polyenoic fatty acids including eicosatrienoate and docosahexaenoate to the corresponding (n-6)S-hydroperoxy derivatives. In turn, this production of bioactive lipid mediators promotes bacterial persistence in host lung tissues by inhibiting the expression of major chemokines and recruitment of leukocytes.
  
  
 0.936
PA3886
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
      
 0.880
PA4140
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
    0.833
PA4139
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
0.770
tadA
TadA ATPase; Class 2: Function of highly similar gene experimentally demonstrated in another organism (and gene context consistent in terms of pathways its involved in (if known).
      
 0.768
PA4624
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
 0.712
PA4625
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
 0.603
PA2204
Probable binding protein component of ABC transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
      
 0.590
flp
Type IVb pilin, Flp; Class 1: Function experimentally demonstrated in P. aeruginosa.
   
  
 0.569
armR
Antirepressor for MexR, ArmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
      
 0.491
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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