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aprF aprF aprE aprE aprD aprD aprA aprA aprI aprI PA1245 PA1245 pvdT pvdT mexH mexH PA5047 PA5047 PA1435 PA1435 PA4374 PA4374
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
aprFAlkaline protease secretion outer membrane protein AprF precursor; Involved in the secretion of alkaline protease; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (481 aa)    
Predicted Functional Partners:
aprE
Alkaline protease secretion protein AprE; Involved in the secretion of alkaline protease; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.999
aprD
Alkaline protease secretion protein AprD; Involved in the secretion of alkaline protease; Belongs to the ABC transporter superfamily. Alkaline protease exporter (TC 3.A.1.110.4) family.
 
  
 0.998
aprA
Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.
 
  
 0.967
aprI
Alkaline proteinase inhibitor AprI; Inhibitor of the alkaline protease. It forms a non-covalent bond with the protease and may prevent its autocatalytic cleavage in the periplasm (By similarity).
  
  
 0.894
PA1245
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
  
    0.877
pvdT
PvdT; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 0.815
mexH
Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.759
PA5047
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
  
   
 0.757
PA1435
Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.745
PA4374
Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.744
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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