node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Veis_0360 | Veis_4403 | Veis_0360 | Veis_4403 | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | 0.650 |
Veis_0360 | Veis_4482 | Veis_0360 | Veis_4482 | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | KEGG: pol:Bpro_2940 ATPase AAA-2; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | 0.870 |
Veis_0360 | clpB | Veis_0360 | Veis_3599 | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.870 |
Veis_0360 | clpX | Veis_0360 | Veis_4372 | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.973 |
Veis_0360 | def | Veis_0360 | Veis_3612 | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.634 |
Veis_0360 | def-2 | Veis_0360 | Veis_4082 | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.595 |
Veis_0360 | groL | Veis_0360 | Veis_2567 | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.660 |
Veis_0360 | groS | Veis_0360 | Veis_2566 | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.684 |
Veis_0360 | grpE | Veis_0360 | Veis_0980 | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.593 |
Veis_0360 | hrcA | Veis_0360 | Veis_1050 | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.694 |
Veis_4403 | Veis_0360 | Veis_4403 | Veis_0360 | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | 0.650 |
Veis_4403 | Veis_4482 | Veis_4403 | Veis_4482 | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | KEGG: pol:Bpro_2940 ATPase AAA-2; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | 0.544 |
Veis_4403 | clpB | Veis_4403 | Veis_3599 | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.544 |
Veis_4403 | clpX | Veis_4403 | Veis_4372 | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.521 |
Veis_4403 | groL | Veis_4403 | Veis_2567 | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.908 |
Veis_4403 | groS | Veis_4403 | Veis_2566 | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.986 |
Veis_4403 | grpE | Veis_4403 | Veis_0980 | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.897 |
Veis_4403 | hrcA | Veis_4403 | Veis_1050 | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.627 |
Veis_4482 | Veis_0360 | Veis_4482 | Veis_0360 | KEGG: pol:Bpro_2940 ATPase AAA-2; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | PFAM: peptidase S14, ClpP; KEGG: pau:PA14_21030 putative ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family. | 0.870 |
Veis_4482 | Veis_4403 | Veis_4482 | Veis_4403 | KEGG: pol:Bpro_2940 ATPase AAA-2; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | 0.544 |