node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Plim_1241 | Plim_1557 | Plim_1241 | Plim_1557 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | 0.680 |
Plim_1241 | hisA | Plim_1241 | Plim_2080 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: maq:Maqu_3171 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase. | 0.827 |
Plim_1241 | hisB | Plim_1241 | Plim_3413 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | Imidazoleglycerol-phosphate dehydratase. | 0.841 |
Plim_1241 | hisC | Plim_1241 | Plim_3414 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.723 |
Plim_1241 | hisD | Plim_1241 | Plim_2170 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.709 |
Plim_1241 | hisF | Plim_1241 | Plim_2829 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.851 |
Plim_1241 | hisG | Plim_1241 | Plim_2331 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.543 |
Plim_1241 | hisH | Plim_1241 | Plim_2081 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.824 |
Plim_1241 | hisI | Plim_1241 | Plim_2330 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.840 |
Plim_1557 | Plim_1241 | Plim_1557 | Plim_1241 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | 0.680 |
Plim_1557 | hisA | Plim_1557 | Plim_2080 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: maq:Maqu_3171 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase. | 0.947 |
Plim_1557 | hisB | Plim_1557 | Plim_3413 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | Imidazoleglycerol-phosphate dehydratase. | 0.947 |
Plim_1557 | hisC | Plim_1557 | Plim_3414 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.883 |
Plim_1557 | hisD | Plim_1557 | Plim_2170 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.946 |
Plim_1557 | hisF | Plim_1557 | Plim_2829 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.947 |
Plim_1557 | hisG | Plim_1557 | Plim_2331 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.994 |
Plim_1557 | hisH | Plim_1557 | Plim_2081 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.947 |
Plim_1557 | hisI | Plim_1557 | Plim_2330 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.994 |
Plim_1557 | tadA | Plim_1557 | Plim_3619 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pau:PA14_66950 phosphoribosyl-ATP pyrophosphatase. | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.781 |
hisA | Plim_1241 | Plim_2080 | Plim_1241 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: maq:Maqu_3171 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase. | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rle:pRL110220 putative exported acid phosphatase. | 0.827 |