node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA1591 | braB | PA1591 | PA1590 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | 0.537 |
PA2653 | braB | PA2653 | PA1590 | Probable transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | 0.487 |
braB | PA1591 | PA1590 | PA1591 | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | 0.537 |
braB | PA2653 | PA1590 | PA2653 | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | Probable transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.487 |
braB | braC | PA1590 | PA1074 | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | Branched-chain amino acid transport protein BraC; Component of the high-affinity leucine, isoleucine, valine transport system I (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids; Belongs to the leucine-binding protein family. | 0.712 |
braB | braD | PA1590 | PA1073 | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | Branched-chain amino acid transport protein BraD; Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids; Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily. | 0.418 |
braB | hcp1 | PA1590 | PA0085 | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family. | 0.414 |
braB | rcsF | PA1590 | PA3388 | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | 0.497 |
braB | sstT | PA1590 | PA2042 | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | Probable transporter (membrane subunit); Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. | 0.473 |
braB | sucC | PA1590 | PA1588 | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Can also generate UTP or CTP, although it preferentially synthesizes ATP and/or GTP. | 0.454 |
braB | sucD | PA1590 | PA1589 | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. Can also generate UTP or CTP, although it preferentially synthesizes ATP and/or GTP. | 0.454 |
braB | xpt | PA1590 | PA5298 | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.476 |
braC | braB | PA1074 | PA1590 | Branched-chain amino acid transport protein BraC; Component of the high-affinity leucine, isoleucine, valine transport system I (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids; Belongs to the leucine-binding protein family. | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | 0.712 |
braC | braD | PA1074 | PA1073 | Branched-chain amino acid transport protein BraC; Component of the high-affinity leucine, isoleucine, valine transport system I (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids; Belongs to the leucine-binding protein family. | Branched-chain amino acid transport protein BraD; Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids; Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily. | 0.999 |
braD | braB | PA1073 | PA1590 | Branched-chain amino acid transport protein BraD; Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids; Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily. | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | 0.418 |
braD | braC | PA1073 | PA1074 | Branched-chain amino acid transport protein BraD; Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids; Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily. | Branched-chain amino acid transport protein BraC; Component of the high-affinity leucine, isoleucine, valine transport system I (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids; Belongs to the leucine-binding protein family. | 0.999 |
hcp1 | braB | PA0085 | PA1590 | Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family. | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | 0.414 |
rcsF | braB | PA3388 | PA1590 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | 0.497 |
sstT | braB | PA2042 | PA1590 | Probable transporter (membrane subunit); Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | 0.473 |
sucC | braB | PA1588 | PA1590 | succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Can also generate UTP or CTP, although it preferentially synthesizes ATP and/or GTP. | Branched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. | 0.454 |