node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA0399 | PA0400 | PA0399 | PA0400 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.999 |
PA0399 | metE | PA0399 | PA1927 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.951 |
PA0399 | metF | PA0399 | PA0430 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 5,10-methylenetetrahydrofolate reductase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the methylenetetrahydrofolate reductase family. | 0.498 |
PA0399 | metG | PA0399 | PA3482 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.459 |
PA0399 | metH | PA0399 | PA1843 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.951 |
PA0399 | metK | PA0399 | PA0546 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.672 |
PA0399 | metY | PA0399 | PA5025 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Homocysteine synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.980 |
PA0399 | metZ | PA0399 | PA3107 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. Cannot use the other activated form of L-homoserine, O-acetyl-L-homoserine, as a substrate. | 0.992 |
PA0399 | sahH | PA0399 | PA0432 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.959 |
PA0400 | PA0399 | PA0400 | PA0399 | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.999 |
PA0400 | metE | PA0400 | PA1927 | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.966 |
PA0400 | metF | PA0400 | PA0430 | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 5,10-methylenetetrahydrofolate reductase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the methylenetetrahydrofolate reductase family. | 0.733 |
PA0400 | metG | PA0400 | PA3482 | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.945 |
PA0400 | metH | PA0400 | PA1843 | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.977 |
PA0400 | metK | PA0400 | PA0546 | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.474 |
PA0400 | metY | PA0400 | PA5025 | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Homocysteine synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.890 |
PA0400 | metZ | PA0400 | PA3107 | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. Cannot use the other activated form of L-homoserine, O-acetyl-L-homoserine, as a substrate. | 0.831 |
PA0400 | sahH | PA0400 | PA0432 | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.890 |
metE | PA0399 | PA1927 | PA0399 | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.951 |
metE | PA0400 | PA1927 | PA0400 | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Probable cystathionine gamma-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.966 |