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pqqH pqqH pqqB pqqB pqqE pqqE pqqD pqqD pqqC pqqC pqqF pqqF ercS ercS pqqA pqqA PA3760 PA3760 exaA exaA PA1991 PA1991
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pqqHPqqH; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (608 aa)    
Predicted Functional Partners:
pqqB
Pyrroloquinoline quinone biosynthesis protein B; May be involved in the transport of PQQ or its precursor to the periplasm; Belongs to the PqqB family.
 
  
 0.991
pqqE
Pyrroloquinoline quinone biosynthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
 
  
 0.990
pqqD
Pyrroloquinoline quinone biosynthesis protein D; Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
  
  
 0.978
pqqC
Pyrroloquinoline quinone biosynthesis protein C; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ.
 
  
 0.976
pqqF
Pyrroloquinoline quinone biosynthesis protein F; Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. It is thought that this protein is a protease that cleaves peptides bond in a small peptide (gene pqqA), providing the glutamate and tyrosine residues which are necessary for the synthesis of PQQ (By similarity).
  
  
 0.916
ercS
ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
 
    0.765
pqqA
Pyrroloquinoline quinone biosynthesis protein A; Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide (By similarity); Belongs to the PqqA family.
  
    0.720
PA3760
N-Acetyl-D-Glucosamine phosphotransferase system transporter; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
   
 
 0.636
exaA
Quinoprotein ethanol dehydrogenase; Catalyzes the oxidation of primary alcohols to the corresponding aldehydes, except for methanol, which is a very poor substrate. ExaA is also able to use secondary alcohols as well as amino alcohols like ethanolamine and l-amino-2-propanol, and aldehydes as substrates; Belongs to the bacterial PQQ dehydrogenase family.
 
    0.615
PA1991
Probable iron-containing alcohol dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
  
 0.604
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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