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ptxS ptxS PA2261 PA2261 PA2260 PA2260 hexR hexR fruI fruI PA3760 PA3760 ptxR ptxR toxA toxA gltB gltB gnuT gnuT PA2262 PA2262
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptxSTranscriptional regulator PtxS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (340 aa)    
Predicted Functional Partners:
PA2261
Probable 2-ketogluconate kinase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
  
 0.943
PA2260
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
 
  
 0.939
hexR
Probable transcriptional regulator; Involved in regulation of glucose metabolism. Transcriptional repressor of the gap-1 gene and of the edd-glk-gltR-2 and zwf-pgl-eda operons. Acts by binding directly to an inverted pseudopalindromic sequence in the promoter region.
  
   
 0.921
fruI
Phosphotransferase system transporter enzyme I, FruI; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the PEP-utilizing enzyme family.
 
 
 0.911
PA3760
N-Acetyl-D-Glucosamine phosphotransferase system transporter; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
  
 
 0.890
ptxR
Transcriptional regulator PtxR; Transcriptional activator of the toxA (exotoxin) and regA genes.
      
 0.883
toxA
Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38.
      
 0.880
gltB
Glutamate synthase large chain precursor; Product name confidence: Class 2 (High similarity to functionally studied protein).
    
 
 0.860
gnuT
Gluconate permease; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the GntP permease family.
  
  
 0.858
PA2262
Probable 2-ketogluconate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
 0.853
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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