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PA2591 PA2591 PA2592 PA2592 rhlR rhlR rocS1 rocS1 PA0600 PA0600 PA4112 PA4112 gacS gacS rhlI rhlI eraS eraS PA1243 PA1243 PA3921 PA3921
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PA2591Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (268 aa)    
Predicted Functional Partners:
PA2592
Probable periplasmic spermidine/putrescine-binding protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
    0.830
rhlR
Transcriptional regulator RhlR; Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone).
 
 
 0.802
rocS1
Probable two-component sensor; Class 1: Function experimentally demonstrated in P. aeruginosa.
   
 
 0.758
PA0600
Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
 
 0.691
PA4112
Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
 
 0.681
gacS
Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 
 0.669
rhlI
Autoinducer synthesis protein RhlI; Required for the synthesis of BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone) autoinducer molecules which bind to RhlR and thus acts in elastase biosynthesis regulation.
  
  
 0.662
eraS
Sensor kinase, EraS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
 
 
 0.609
PA1243
Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
 
 0.589
PA3921
Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
  
 0.530
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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