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cobN cobN cobB cobB cobL cobL cobW cobW cobO cobO PA2909 PA2909 cobH cobH PA1923 PA1923 cbiD cbiD cobU cobU PA4399 PA4399
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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cobNCobalamin biosynthetic protein CobN; Catalyzes cobalt insertion in the corrin ring. (1248 aa)    
Predicted Functional Partners:
cobB
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
 
 0.991
cobL
Precorrin-6y-dependent methyltransferase CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X.
 
  
 0.989
cobW
Conserved hypothetical protein; Might be involved in cobalt reduction leading to cobalt(I) corrinoids; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
 
  
 0.989
cobO
cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity).
 
 
 0.979
PA2909
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
 
  
 0.958
cobH
Precorrin isomerase CobH; Catalyzes the conversion of precorrin-8X to hydrogenobyrinate; Belongs to the CobH/CbiC family.
 
  
 0.948
PA1923
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
  
 
0.944
cbiD
Cobalamin biosynthetic protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.934
cobU
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
 
  
 0.929
PA4399
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); Belongs to the Cob(I)alamin adenosyltransferase family.
  
 
 0.919
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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