STRINGSTRING
nagZ nagZ amgK amgK anmK anmK ampD ampD ampG ampG mpl mpl ampC ampC ampR ampR PA3004 PA3004 ampDh2 ampDh2 amiB amiB
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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nagZbeta-N-acetyl-D-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides (By similarity). Contributes to intrinsic fosfomycin resistance in P.aeruginosa ; Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (332 aa)    
Predicted Functional Partners:
amgK
Hypothetical protein; Sugar kinase that catalyzes the ATP-dependent phosphorylation of N-acetylmuramate (MurNAc) and N-acetylglucosamine (GlcNAc) at its C1 hydroxyl group, leading to MurNAc alpha-1P and GlcNAc alpha-1P, respectively (By similarity). Is involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc. Plays a role in intrinsic resistance to fosfomycin, which targets the de novo synthesis of UDP-MurNAc.
 
  
 0.982
anmK
Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P (By similarity). Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Contributes to intrinsic fosfomycin resistance in P.aeruginosa.
 
 
 0.975
ampD
Beta-lactamase expression regulator AmpD; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
  
 0.955
ampG
AmpG; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
 
  
 0.931
mpl
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily.
 
  
 0.904
ampC
Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family.
  
  
 0.903
ampR
Transcriptional regulator AmpR; This protein is a positive regulator of gene expression of beta-lactamase (AmpC); Belongs to the LysR transcriptional regulatory family.
      
 0.884
PA3004
5-methylthioadenosine phosphorylase MtnP; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. Involved in quorum sensing; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
  
  
 0.877
ampDh2
AmpDh2; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
     
 0.847
amiB
N-acetylmuramoyl-L-alanine amidase; Product name confidence: Class 2 (High similarity to functionally studied protein).
    
 0.826
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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