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asd asd dapA dapA hom hom lysC lysC pvdH pvdH PA0223 PA0223 PA4188 PA4188 leuB leuB PA3018 PA3018 gltB gltB PA1254 PA1254
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. (370 aa)    
Predicted Functional Partners:
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). Belongs to the DapA family.
  
 
 0.988
hom
Homoserine dehydrogenase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
 0.977
lysC
Aspartate kinase alpha and beta chain; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the aspartokinase family.
 
 
 0.975
pvdH
L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase, PvdH; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
    
 0.938
PA0223
Probable dihydrodipicolinate synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the DapA family.
  
 
 0.937
PA4188
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); Belongs to the DapA family.
  
 
 0.937
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
  
  
 0.891
PA3018
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
      
 0.807
gltB
Glutamate synthase large chain precursor; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
  
 0.694
PA1254
Probable dihydrodipicolinate synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the DapA family.
  
 
 0.685
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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