node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dusC | micA | PA3129 | PA0382 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | DNA mismatch repair protein MicA; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | 0.677 |
dusC | rimI | PA3129 | PA4678 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | Peptide n-acetyltransferase RimI; Acetylates the N-terminal alanine of ribosomal protein S18. | 0.677 |
dusC | rluA | PA3129 | PA3246 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | Pseudouridine synthase RluA; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.814 |
dusC | thiI | PA3129 | PA5118 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | Thiazole biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.698 |
dusC | tilS | PA3129 | PA3638 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | Conserved hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.817 |
dusC | trmL | PA3129 | PA5127 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | Probable rRNA methylase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.679 |
dusC | trmU | PA3129 | PA2626 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | tRNA methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.784 |
dusC | truA | PA3129 | PA3114 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | tRNA-pseudouridine synthase I; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.740 |
dusC | truB | PA3129 | PA4742 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | tRNA pseudouridine 55 synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity). Osmoprotectant regulator of PLC; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.876 |
dusC | ttcA | PA3129 | PA1192 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | Conserved hypothetical protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. | 0.678 |
micA | dusC | PA0382 | PA3129 | DNA mismatch repair protein MicA; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | 0.677 |
micA | rluA | PA0382 | PA3246 | DNA mismatch repair protein MicA; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | Pseudouridine synthase RluA; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.861 |
micA | thiI | PA0382 | PA5118 | DNA mismatch repair protein MicA; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | Thiazole biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.824 |
micA | tilS | PA0382 | PA3638 | DNA mismatch repair protein MicA; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | Conserved hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.697 |
micA | trmL | PA0382 | PA5127 | DNA mismatch repair protein MicA; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | Probable rRNA methylase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.903 |
micA | trmU | PA0382 | PA2626 | DNA mismatch repair protein MicA; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | tRNA methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.646 |
micA | truA | PA0382 | PA3114 | DNA mismatch repair protein MicA; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | tRNA-pseudouridine synthase I; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.938 |
micA | truB | PA0382 | PA4742 | DNA mismatch repair protein MicA; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | tRNA pseudouridine 55 synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity). Osmoprotectant regulator of PLC; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.962 |
micA | ttcA | PA0382 | PA1192 | DNA mismatch repair protein MicA; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | Conserved hypothetical protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. | 0.841 |
rimI | dusC | PA4678 | PA3129 | Peptide n-acetyltransferase RimI; Acetylates the N-terminal alanine of ribosomal protein S18. | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | 0.677 |