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PA3131 PA3131 edd edd eda eda pgi pgi PA2323 PA2323 glcB glcB glcE glcE glcD glcD aceA aceA PA3896 PA3896 glcF glcF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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[Homology]
Score
PA3131Probable aldolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (215 aa)    
Predicted Functional Partners:
edd
Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family.
 
 
 0.981
eda
2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family.
  
 
0.912
pgi
Glucose-6-phosphate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 
 0.911
PA2323
Probable glyceraldehyde-3-phosphate dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
 
 0.910
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
     
 0.909
glcE
Glycolate oxidase subunit GlcE; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
 
 0.907
glcD
Glycolate oxidase subunit GlcD; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
 
 0.907
aceA
Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.
     
 0.906
PA3896
Probable 2-hydroxyacid dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
  0.904
glcF
Glycolate oxidase subunit GlcF; Product name confidence: Class 2 (High similarity to functionally studied protein).
     
 0.904
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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