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amiS amiS amiR amiR amiB-2 amiB-2 amiE amiE amiC amiC speC speC PA4858 PA4858 qteE qteE ureD ureD ureC ureC ureE ureE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
amiSHypothetical protein; Possible transporter that might be responsible for the adsorption of amidase substrates or release of their hydrolysis products. AmiB and AmiS may act jointly in to a two component ABC transporter system; Belongs to the AmiS/UreI family. (172 aa)    
Predicted Functional Partners:
amiR
Aliphatic amidase regulator; Positive controlling element of AmiE, the gene for aliphatic amidase. Acts as a transcriptional antitermination factor. It is thought to allow RNA polymerase read through a rho-independent transcription terminator between the AmiE promoter and gene.
 
  
 0.968
amiB-2
Probable chaperone; Unlikely to encode a regulatory protein. Has ATPase activity. AmiB and AmiS may act jointly into a two component ABC transporter system; Belongs to the ClpX chaperone family.
  
  
 0.956
amiE
Aliphatic amidase; Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia. Enables the organism to use acetamide as both carbon and nitrogen source; Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
 
  
 0.945
amiC
Aliphatic amidase expression-regulating protein; Negatively regulates the expression of the aliphatic amidase operon. AmiC functions by inhibiting the action of AmiR at the protein level. It exhibits protein kinase activity.
  
  
 0.917
speC
Ornithine decarboxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the Orn/Lys/Arg decarboxylase class-II family.
   
  
 0.768
PA4858
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
     
 0.761
qteE
Quorum threshold expression element, QteE; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
      
 0.560
ureD
Urease accessory protein; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
     
 0.455
ureC
Urease alpha subunit; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
     
 0.454
ureE
Urease accessory protein UreE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.
     
 0.454
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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