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folE1 folE1 folX folX PA2666 PA2666 folE2-2 folE2-2 folK folK ribB ribB folB folB folP folP ribA ribA eddA eddA moaA2 moaA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
folE1GTP cyclohydrolase I precursor; Product name confidence: Class 2 (High similarity to functionally studied protein). (186 aa)    
Predicted Functional Partners:
folX
D-erythro-7,8-dihydroneopterin triphosphate epimerase; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
  
 
 0.995
PA2666
Probable 6-pyruvoyl tetrahydrobiopterin synthase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
 
 0.993
folE2-2
Hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate.
     
 0.954
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the HPPK family.
  
 0.948
ribB
GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family.
  
 
 0.944
folB
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
  
 0.942
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 0.933
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
   
 
 0.922
eddA
Extracelullar DNA degradation protein, EddA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
    
 0.917
moaA2
Molybdopterin biosynthetic protein A2; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
  
 
  0.914
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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