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tse3 tse3 tsi3 tsi3 tsi1 tsi1 vgrG1 vgrG1 tsi2 tsi2 tse2 tse2 tse4 tse4 tse1 tse1 pldA pldA clpV1 clpV1 PA3483 PA3483
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
tse3Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin. (408 aa)    
Predicted Functional Partners:
tsi3
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse3. Occupies Tse3 substrate binding site and prevents the substrate from entering.
  
 
 0.999
tsi1
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse1. Binds to a large surface of Tse1 and thereby occludes the active site to specifically inhibits enzyme activity by forming a hydrogen bond with the catalytic diad.
   
  
 0.931
vgrG1
VgrG1; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1. Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity.
   
  
 0.915
tsi2
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse2. Binds to a large surface of Tse2 and thereby occludes the active site to specifically inhibits Tse2.
   
  
 0.907
tse2
Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells. Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells.
   
  
 0.901
tse4
Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells.
   
  
 0.890
tse1
Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin.
   
  
 0.888
pldA
Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
  
  
 0.883
clpV1
ClpV1; Required for secretion of hcp1 probably by providing the energy source for its translocation; Belongs to the ClpA/ClpB family.
   
  
 0.869
PA3483
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
  
    0.859
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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