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tsi3 tsi3 tse3 tse3 tse2 tse2 tsi2 tsi2 tse1 tse1 tsi1 tsi1 tse5 tse5 tse4 tse4 vgrG1 vgrG1 tsi6 tsi6 tse6 tse6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
tsi3Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse3. Occupies Tse3 substrate binding site and prevents the substrate from entering. (145 aa)    
Predicted Functional Partners:
tse3
Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin.
  
 
 0.999
tse2
Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells. Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells.
   
  
 0.902
tsi2
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse2. Binds to a large surface of Tse2 and thereby occludes the active site to specifically inhibits Tse2.
   
  
 0.901
tse1
Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin.
   
  
 0.896
tsi1
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse1. Binds to a large surface of Tse1 and thereby occludes the active site to specifically inhibits enzyme activity by forming a hydrogen bond with the catalytic diad.
   
  
 0.895
tse5
Conserved hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system that acts on bacterial target cells. The producing bacterium is protected by a cognate immunity protein.
   
  
 0.813
tse4
Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells.
   
  
 0.793
vgrG1
VgrG1; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1. Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity.
   
  
 0.761
tsi6
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse5.
   
  
 0.715
tse6
Hypothetical protein; Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis. The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6.
   
  
 0.715
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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