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pyrC pyrC pyrB pyrB pyrD pyrD pyrC-2 pyrC-2 pyrQ pyrQ dht dht rnt rnt carA carA carB carB PA0439 PA0439 pyrE pyrE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
 
 0.994
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
 
 
 0.982
pyrC-2
Noncatalytic dihydroorotase-like protein; Non-functional DHOase; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. PyrC' subfamily.
  
 
 0.979
pyrQ
Dihydroorotase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
    
 0.906
dht
Dihydropyrimidinase; Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N- carbamoyl-D-amino acids.
     
 0.889
rnt
Ribonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.
  
  
 0.874
carA
Carbamoyl-phosphate synthase small chain; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the CarA family.
   
  
 0.823
carB
Carbamoylphosphate synthetase large subunit; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
   
  
 0.809
PA0439
Probable oxidoreductase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
  
 0.717
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.702
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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